Ricardo Amado Armisen

Líneas de investigación

• Oncología de Precisión

Proyectos adjudicados

• UNRAVELING THE MECHANISM BEHIND SKI-DEPENDENT TRI-METHYLATION OF LYS9 IN HISTONE H3 IN PERICENTRIC HETEROCHROMATIN AND ITS ROLE IN THE MAINTENANCE OF GENOME STABILITY (2022) Fuente: CONICYT | Rol:
• UNCOVERING NOVEL DRIVER MUTATIONS IN NON-SMALL CELL LUNG CANCER FROM CHILE BRAZIL AND PERÚ PATIENTS (2021) Fuente: CONICYT | Rol:
• DISCOVERY OF NOVEL ACTIONABLE GENOMIC ALTERATIONS IN SOUTH AMERICA PATIENTS (2021) Fuente: ROCHE/GOCCHI | Rol:
• ADAR PROMOTES BREAST CANCER PROGRESSION THROUGH THE REGULATION OF CELL CYCLE AND DNA REPAIR RELATED GENES (2015) Fuente: CONICYT | Rol:
• CENTER FOR EXCELLENCE IN PRECISION MEDICINE PFIZER CHILE (2015) Fuente: CORFO | Rol:
• ROLE OF SKI/SMAD4 COMPLEX ON THE ESTABLISHMENT OF EPIGENETIC MODIFICATIONS OF PERICENTROMERIC CHROMATIN REQUIRED FOR PROPER CHROMOSOME SEGREGATION (2015) Fuente: CONICYT | Rol:
• BIOBANCO FACULTAD DE MEDICINA-HCUCH: ALIANZA ESTRATÉGICA ENTRE LA FACULTAD DE MEDICINA - HOSPITAL CLÍNICO (2014) Fuente: Universidad de Chile | Rol:
• BIOMED-HPC: RED DE BIOLOGÍA Y MEDICINA COMPUTACIONAL DE ALTO RENDIMIENTO (2014) Fuente: Universidad de Chile | Rol:
• INSTALACION DE UNA PLATAFORMA DE GENOMICA MULTIPROPOSITO EN LA UNIVERSIDAD DE CHILE: ILLUMINA NEXTSEQ 550 (2014) Fuente: CONICYT | Rol:
• SISTEMA DE ALMACENAMIENTO Y SERVICIOS INFORMÁTICOS BIOMÉDICOS AVANZADOS SASIBA DATA CENTER (2014) Fuente: CONICYT | Rol:
• TRAINING CHILEAN BIOINFORMATICS RESEARCHERS IN THE CANCER GENOMICS FIELD (2014) Fuente: National Cancer Institue | Rol:
• INCORPORACIÓN DE LA SECUENCIACIÓN DE ÚLTIMA GENERACIÓN EN EL CUIDADO DE LOS PACIENTES CON CÁNCER (2013) Fuente: CONICYT | Rol:
• LIPOPOLYSACCHARIDE INDUCES EPITHELIAL-MESENCHYMAL TRANSITION OF THE BLADDER UROTHELIUM (2013) Fuente: CONICYT | Rol:
• PLASMA PHYSICS PULSED POWER AND CELL BIOLOGY FOR ENERGY LIFE AND ENVIRONMENT (2013) Fuente: CONICYT | Rol:
• MOLECULAR PROFILING OF STAGE II AND III BREAST CANCER IN LATIN AMERICAN WOMEN RECEIVING STANDARD OF CARE TREATMENT (2012) Fuente: National Cancer Institue | Rol:
• PROTEIN KINASE CK2 PROMOTES COLON CANCER METASTASIS BY INCREASING THE EXPRESSION OF ENDOTHELIN-CONVERTING ENZYME-1 ISOFORM C ECE-1C (2012) Fuente: CONICYT | Rol:
• RED U-CÁNCER UNA PLATAFORMA EN LÍNEA DE INVESTIGACIÓN BÁSICO-CLÍNICO DE CÁNCER EN CHILE (2012) Fuente: CONICYT | Rol:
• SKI-CONTAINING TRANSCRIPTIONAL CO-REPRESSOR COMPLEXES ON MITOTIC CHROMOSOMES REPRESS THE EXPRESSION OF SELECTED TARGET GENES AT EARLY G1 (2012) Fuente: CONICYT | Rol:
• THE TRANSIENT RECEPTOR POTENTIAL MELASTATIN 4 TRPM4 CHANNEL STABILIZES B-CATENIN AND THEREFORE ENHANCES CELL PROLIFERATION THROUGH A CALCIUM-DEPENDENT NEGATIVE REGULATION OF GSK-3B ACTIVITY (2012) Fuente: CONICYT | Rol:
• U-CANCER: RED DE MEDICINA TRASLACIONAL EN CÁNCER (2012) Fuente: Universidad de Chile | Rol:
• CENTRO DE ESTUDIOS MOLECULARES DE LA CÉLULA (2006) Fuente: CONICYT | Rol:
• DESARROLLO Y VALIDACIÓN A PEQUEÑA ESCALA DE UN ENSAYO PARA LA DETECCIÓN DE MUTACIONES TUMORALES EN BIOPSIA LÍQUIDA DE PACIENTES CON CÁNCER DE MAMA AVANZADO (2021) Fuente: ANID(Santiago;RM;CL) | Rol:
• LANDSCAPE OF CLINICALLY ACTIONABLE CANCER GENES: TOWARDS PRECISION ONCOLOGY IN CHILE (2021) Fuente: ANID(Santiago;RM;CL) | Rol:
• ADENOSINE DEAMINASE RNA SPECIFIC (ADAR) REGULATES THE BREAST CANCER DRUG RESPONSE. (2022) Fuente: ANID(Santiago;RM;CL) | Rol:
• UNCOVERING NOVEL DRIVER MUTATIONS IN NON-SMALL CELL LUNG CANCER FROM CHILE BRAZIL AND PERU PATIENTS PI DRA. SOLANGE RIVAS (2021) Fuente: FONDECYT(Santiago;CL) | Rol:
• ANALYTICAL VALIDATION AND COST DOCUMENTATION OF AN NGS METHODOLOGY FOR THE ROUTINE DIAGNOSIS OF MULTIPLE ACTIONABLE MOLECULAR ALTERATIONS FOR THE TREATMENT OF LUNG CANCER PATIENTS IN THE CHILEAN PUBLIC HEALTH SYSTEM (2022-2024). (2023) Fuente: Roche(Santiago;CL) | Rol:

Tus publicaciones

• TOTAL MUTATIONAL LOAD AND CLINICAL FEATURES AS PREDICTORS OF THE METASTATIC STATUS IN LUNG ADENOCARCINOMA AND SQUAMOUS CELL CARCINOMA PATIENTS Autores: Karen Y. Oróstica;Juan Saez-Hidalgo;Pamela R. de Santiago;Solange Rivas;Sebastian Contreras;Gonzalo Navarro;Juan A. Asenjo;Álvaro Olivera-Nappa;Ricardo Armisén; Año: 2022 Link: https://doi.org/10.1186/s12967-022-03572-8
• SOCIOECONOMIC CLINICAL AND MOLECULAR FEATURES OF BREAST CANCER INFLUENCE OVERALL SURVIVAL OF LATIN AMERICAN WOMEN. Autores: de Almeida LM;Cortés S;Vilensky M;Valenzuela O;Cortes-Sanabria L;de Souza M;Barbeito RA;Abdelhay E;Artagaveytia N;Daneri-Navarro A;United States-Latin American Cancer Research Network (US-LACRN); Año: 2022 Link: https://doi.org/35530311
• THE TRANSCRIPTOMIC PORTRAIT OF LOCALLY ADVANCED BREAST CANCER AND ITS PROGNOSTIC VALUE IN A MULTI-COUNTRY COHORT OF LATIN AMERICAN PATIENTS. Autores: Llera AS;Abdelhay ESFW;Artagaveytia N;Daneri-Navarro A;Müller B;Velazquez C;Alcoba EB;Alonso I;Alves da Quinta DB;Binato R;Bravo AI;Podhajcer OL; Año: 2022 Link: https://doi.org/35433488
• EL CÁNCER DE PULMÓN DE CÉLULAS NO PEQUEÑAS EN LA ERA DE LA MEDICINA DE PRECISIÓN Año: 2022 Link: https://doi.org/10.1016/j.rmclc.2022.01.001
• ERRATUM: PRION PROTEIN MISFOLDING AFFECTS CALCIUM HOMEOSTASIS AND SENSITIZES CELLS TO ENDOPLASMIC RETICULUM STRESS (PLOS ONE (2021) 5:12 (E15658) DOI: 10.1371/JOURNAL.PONE.0015658) Autores: Torres, M.;Castillo, K.;Armisén, R.;Stutzin, A.;Soto, C.;Hetz, C.; Año: 2022 Link: https://doi.org/10.1371/journal.pone.0262628
• INCREASE IN ADAR1P110 ACTIVATES THE CANONICAL WNT SIGNALING PATHWAY ASSOCIATED WITH AGGRESSIVE PHENOTYPE IN TRIPLE NEGATIVE BREAST CANCER CELLS Autores: Morales, F.;Pérez, P.;Tapia, J.C.;Lobos-González, L.;Herranz, J.M.;Guevara, F.;de Santiago, P.R.;Palacios, E.;Andaur, R.;Sagredo, E.A.;Marcelain, K.;Armisén, R.; Año: 2022 Link: https://doi.org/10.1016/j.gene.2022.146246
• A CASE-CONTROL STUDY OF A COMBINATION OF SINGLE NUCLEOTIDE POLYMORPHISMS AND CLINICAL PARAMETERS TO PREDICT CLINICALLY RELEVANT TOXICITY ASSOCIATED WITH FLUOROPYRIMIDINE AND PLATINUM-BASED CHEMOTHERAPY IN GASTRIC CANCER Año: 2021 Link: https://doi.org/10.1186/s12885-021-08745-0
• VALIDATION OF AN NGS PANEL DESIGNED FOR DETECTION OF ACTIONABLE MUTATIONS IN TUMORS COMMON IN LATIN AMERICA Autores: Mauricio Salvo;Evelin González-Feliú;Jessica Toro;Iván Gallegos;Ignacio Maureira Caviedes;Nicolás Miranda-González;Olga Barajas;Eva Bustamante;Mónica Ahumada;Alicia Colombo;Ricardo Armisen;Camilo Villamán;Carolina Ibañez;Maria Loreto Bravo;Verónica Sanhueza;M. Loreto Spencer;Gonzalo de Toro;Erik Morales;Carolina Bizama;Patricia García;Ana María Carrasco;Lorena Gutiérrez;Justo Lorenzo Bermejo;Ricardo Verdugo;Katherine Marcelain; Año: 2021 Link: https://doi.org/10.3390/jpm11090899
• CONCORDANCE ANALYSIS OF ALK GENE FUSION DETECTION METHODS IN PATIENTS WITH NONSMALL-CELL LUNG CANCER FROM CHILE BRAZIL AND PERU Año: 2021 Link: https://doi.org/10.1016/j.jmoldx.2021.05.018
• MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I-RELATED CHAIN A (MICA) ALLELIC VARIANTS ASSOCIATE WITH SUSCEPTIBILITY AND PROGNOSIS OF GASTRIC CANCER. Año: 2021 Link: https://doi.org/33868281
• CORRIGENDUM TO: BH3-ONLY PROTEINS ARE PART OF A REGULATORY NETWORK THAT CONTROL THE SUSTAINED SIGNALLING OF THE UNFOLDED PROTEIN RESPONSE SENSOR IRE1: BH3-ONLY CONTROLS THE SUSTAINED SIGNALLING OF IRE1 (THE EMBO JOURNAL (2012) 31 10 (2322-2335) 10.1038/EMBOJ.2012.84) Autores: Rodriguez, D.A.;Zamorano, S.;Lisbona, F.;Rojas-Rivera, D.;Urra, H.;Cubillos-Ruiz, J.R.;Armisen, R.;Henriquez, D.R.;Cheng, E.H.;Letek, M.;Vaisar, T.;Irrazabal, T.;Gonzalez-Billault, C.;Letai, A.;Pimentel-Muiños, F.X.;Kroemer, G.;Hetz, C.; Año: 2021 Link: https://doi.org/10.15252/embj.2021109146
• IMMUNE-RELATED INCRNA LINC00944 RESPONDS TO VARIATIONS IN ADAR1 LEVELS AND IT IS ASSOCIATED WITH BREAST CANCER PROGNOSIS. Autores: de Santiago PR;Blanco A;Morales F;Marcelain K;Harismendy O;Sjberg Herrera M;Armisén R; Año: 2020 Link: https://doi.org/33383047
• A MOLECULAR STRATIFICATION OF CHILEAN GASTRIC CANCER PATIENTS WITH POTENTIAL CLINICAL APPLICABILITY. Autores: Pinto MP;Córdova-Delgado M;Retamal IN;Muñoz-Medel M;Bravo ML;Durán D;Villanueva F;Sanchez C;Acevedo F;Mondaca S;Koch É;Ibañez C;Garrido M; Año: 2020 Link: https://doi.org/32664343
• ADAR1 TRANSCRIPTOME EDITING PROMOTES BREAST CANCER PROGRESSION THROUGH THE REGULATION OF CELL CYCLE AND DNA DAMAGE RESPONSE Autores: Sagredo, E.A.;Sagredo, A.I.;Blanco, A.;Rojas De Santiago, P.;Rivas, S.;Assar, R.;Pérez, P.;Marcelain, K.;Armisén, R.; Año: 2020 Link: https://doi.org/10.1016/j.bbamcr.2020.118716
• SKI IS REQUIRED FOR TRI-METHYLATION OF H3K9 IN MAJOR SATELLITE AND FOR REPRESSION OF PERICENTROMERIC GENES: MMP3 MMP10 AND MMP13 IN MOUSE FIBROBLASTS Autores: Cappelli, C.;Sepulveda, H.;Rivas, S.;Pola, V.;Urzúa, U.;Donoso, G.;Sagredo, E.;Carrero, D.;Casanova-Ortiz, E.;Sagredo, A.;González, M.;Manterola, M.;Nardocci, G.;Armisén, R.;Montecino, M.;Marcelain, K.; Año: 2020 Link: https://doi.org/10.1016/j.jmb.2020.03.013
• MET SIGNALING PATHWAYS RESISTANCE MECHANISMS AND OPPORTUNITIES FOR TARGET THERAPIES Autores: Solange Rivas;Arnaldo Marín;Suraj Samtani;Evelin González-Feliú;Ricardo Armisén; Año: 2022 Link: https://doi.org/10.3390/ijms232213898