Yorley Andrea Duarte Ayala

Líneas de investigación

• Síntesis Orgánica
• Drug Discovery
• Química Médica
• Simulación Molecular

Tus publicaciones

• INNOVATIVE THREE-STEP MICROWAVE-PROMOTED SYNTHESIS OF N-PROPARGYLTETRAHYDROQUINOLINE AND 1,2,3-TRIAZOLE DERIVATIVES AS A POTENTIAL FACTOR XA (FXA) INHIBITORS Autores: Santana-Romo, F., Lagos, F., Duarte, Y., Castillo, F., Moglie, Y., Maestro, A., Charbe, N., Zacconi, C., Año: 2020 Link: https://doi.org/10.3390/molecules25030491
• CATIONIC CARBOSILANE DENDRITIC SYSTEMS AS PROMISING ANTI-AMYLOID AGENTS IN TYPE 2 DIABETES Autores: Lozano-Cruz, T., Alcarraz-Vizán, G., de la Mata, J., de Pablo, S., Ortega, P., Duarte, Y., Bravo-Moraga, F., González-Nilo, D., Novials, A., Gómez, R., Año: 2020 Link: https://doi.org/10.1002/chem.202000091
• NOVEL TRPV1 CHANNEL AGONISTS WITH FASTER AND MORE POTENT ANALGESIC PROPERTIES THAN CAPSAICIN Autores: Duarte, Y., Cáceres, J., Sepúlveda, V., Arriagada, D., Olivares, P., Díaz-Franulic, I., Stehberg, J., González-Nilo, F., Año: 2020 Link: https://doi.org/10.3389/fphar.2020.01040
• PLIDFLOW Autores: Ulzurrun, E., Duarte, Y., Perez-Wohlfeil, E., Gonzalez-Nilo, F., Trelles, O., Año: 2020 Link: https://doi.org/10.1093/bioinformatics/btaa481
• STRUCTURAL DETERMINANTS OF TRPV4 INHIBITION AND IDENTIFICATION OF NEW ANTAGONISTS WITH ANTIVIRAL ACTIVITY Autores: Doñate-Macian, P., Duarte, Y., Rubio-Moscardo, F., Pérez-Vilaró, G., Canan, J., Díez, J., González-Nilo, F., Valverde, A., Año: 2020 Link: https://doi.org/10.1111/bph.15267
• STRETCH-INDUCED ACTIVATION OF PANNEXIN 1 CHANNELS CAN BE PREVENTED BY PKA-DEPENDENT PHOSPHORYLATION Autores: López, X., Escamilla, R., Fernández, P., Duarte, Y., González-Nilo, F., Palacios-Prado, N., Martinez, D., Sáez, C., Año: 2020 Link: https://doi.org/10.3390/ijms21239180
• DIFFERENT CLASSES OF ANTIDEPRESSANTS INHIBIT THE RAT 7 NICOTINIC ACETYLCHOLINE RECEPTOR BY INTERACTING WITHIN THE ION CHANNEL Autores: Duarte, Y., Rojas, M., Canan, J., Pérez, G., González-Nilo, F., García-Colunga, J., Año: 2021 Link: https://doi.org/10.3390/molecules26040998
• DEVELOPMENT OF A PHBV NANOPARTICLE AS A PEPTIDE VEHICLE FOR NOD1 ACTIVATION Autores: Cabaña-Brunod, M., Herrera, A., Márquez-Miranda, V., Llancalahuen, M., Duarte, Y., González-Nilo, D., Fuentes, A., Vilos, C., Velásquez, L., Otero, C., Año: 2021 Link: https://doi.org/10.1080/10717544.2021.1923862
• A PHYSIOLOGIC RISE IN CYTOPLASMIC CALCIUM ION SIGNAL INCREASES PANNEXIN1 CHANNEL ACTIVITY VIA A C-TERMINUS PHOSPHORYLATION BY CAMKII Autores: López, X., Palacios-Prado, N., Güiza, J., Escamilla, R., Fernández, P., Vega, L., Rojas, M., Marquez-Miranda, V., Chamorro, E., Cárdenas, M., Maldifassi, C., Martínez, D., Duarte, Y., González-Nilo, D., Sáez, C., Año: 2021 Link: https://doi.org/10.1073/pnas.2108967118
• ANTI-PARASITIC DRUGS MODULATE THE NON-SELECTIVE CHANNELS FORMED BY CONNEXINS OR PANNEXINS Autores: Güiza, J., Arriagada, J., Rodríguez, L., Gutiérrez, C., Duarte, Y., Sáez, C., Vega, L., Año: 2021 Link: https://doi.org/10.1016/j.bbadis.2021.166188
• ANTIMICROBIAL PROPERTIES OF NOVEL IONIC LIQUIDS DERIVED FROM IMIDAZOLIUM CATION WITH PHENOLIC FUNCTIONAL GROUPS Autores: Guzmán, L., Parra-Cid, C., Guerrero-Muñoz, E., Peña-Varas, C., Polo-Cuadrado, E., Duarte, Y., Castro, I., Nerio, S., Araya-Maturana, R., Assefa, T., Echeverría, J., Ramírez, D., Forero-Doria, O., Año: 2021 Link: https://doi.org/10.1016/j.bioorg.2021.105289
• CONTRIBUTION OF NON-SELECTIVE MEMBRANE CHANNELS AND RECEPTORS IN EPILEPSY Autores: García-Rodríguez, C., Bravo-Tobar, D., Duarte, Y., Barrio, C., Sáez, C., Año: 2021 Link: https://doi.org/10.1016/j.pharmthera.2021.107980
• UNNEXINS Autores: Güiza, J., García, A., Arriagada, J., Gutiérrez, C., González, J., Márquez-Miranda, V., Alegría-Arcos, M., Duarte, Y., Rojas, M., González-Nilo, F., Sáez, C., Vega, L., Año: 2021 Link: https://doi.org/10.1002/jcp.30626
• GREEN BY DESIGN Autores: Rodríguez, F., Durán-Osorio, F., Duarte, Y., Olivares, P., Moglie, Y., Dua, K., Zacconi, C., Año: 2022 Link: https://doi.org/10.3390/pharmaceutics14010033
• MOLECULAR MODELING AND STRUCTURAL ANALYSIS OF SOME TETRAHYDROINDAZOLE AND CYCLOPENTANEPYRAZOLE DERIVATIVES AS COX-2 INHIBITORS Autores: Polo-Cuadrado, E., Acosta-Quiroga, K., Rojas-Peña, C., Rodriguez-Nuñez, A., Duarte, Y., Brito, I., Cisterna, J., Gutiérrez, M., Año: 2022 Link: https://doi.org/10.1016/j.arabjc.2021.103540
• PLIDFLOW: AN OPEN-SOURCE WORKFLOW FOR THE ONLINE ANALYSIS OF PROTEIN-LIGAND DOCKING USING GALAXY Año: 2020 Link: https://doi.org/10.1093/bioinformatics/btaa481
• INNOVATIVE THREE-STEP MICROWAVE-PROMOTED SYNTHESIS OF N-PROPARGYLTETRAHYDROQUINOLINE AND 123-TRIAZOLE DERIVATIVES AS A POTENTIAL FACTOR XA (FXA) INHIBITORS: DRUG DESIGN SYNTHESIS AND BIOLOGICAL EVALUATION. Año: 2020 Link: https://doi.org/10.3390/molecules25030491
• ANTI-PARASITICS DRUGS THAT MODULATES NON-SELECTIVE CHANNELS FORMED BY CONNEXINS OR PANNEXINS Autores: Juan Güiza; Javiera Arriagada; Luis Rodríguez; Camila Gutiérrez; Yorley Duarte; Juan C. Sáez; José L. Vega; Año: 2021 Link: https://doi.org/10.1016/j.bbadis.2021.166188
• DIFFERENT CLASSES OF ANTIDEPRESSANTS INHIBIT THE RAT 7 NICOTINIC ACETYLCHOLINE RECEPTOR BY INTERACTING WITHIN THE ION CHANNEL: A FUNCTIONAL AND STRUCTURAL STUDY Autores: Duarte; Y.; Rojas; M.; Canan; J.; Pérez; E.G.; González-Nilo; F.; García-Colunga; J. Año: 2021 Link: https://doi.org/10.3390/molecules26040998
• DIRECT ORAL FXA INHIBITORS BINDING TO HUMAN SERUM ALBUMIN: SPECTROSCOPIC CALORIMETRIC AND COMPUTATIONAL STUDIES Autores: Marino-Ocampo; Nory; Rodriguez; Diego F.; Guerra Diaz; Daniel; Zuniga-Nunez; Daniel; Duarte; Yorley; Fuentealba; Denis; Zacconi; Flavia C. Año: 2023 Link: https://doi.org/10.3390/ijms24054900
• INSIGHTS INTO EARLY STEPS OF DECANOIC ACID SELF-ASSEMBLIES UNDER PREBIOTIC TEMPERATURES USING MOLECULAR DYNAMICS SIMULATIONS Autores: Sepulveda; R.V.; Sbarbaro; C.; Opazo; M.C.; Duarte; Y.; González-Nilo; F.; Aguayo; D. Año: 2023 Link: https://doi.org/https://doi.org/10.3390/membranes13050469
• ENDOGENOUS PANNEXIN1 CHANNELS FORM FUNCTIONAL INTERCELLULAR CELL-CELL CHANNELS WITH CHARACTERISTIC VOLTAGE-DEPENDENT PROPERTIES Autores: Palacios-Prado; Nicolas; Soto; Paola A.; Lopez; Ximena; Choi; Eun Ju; Marquez-Miranda; Valeria; Rojas; Maximiliano; Duarte; Yorley; Lee; Jinu; Gonzalez-Nilo; Fernando D.; Saez; Juan C. Año: 2022 Link: https://doi.org/10.1073/pnas.2202104119
• GREEN BY DESIGN: CONVERGENT SYNTHESIS COMPUTATIONAL ANALYSES AND ACTIVITY EVALUATION OF NEW FXA INHIBITORS BEARING PEPTIDE TRIAZOLE LINKING UNITS Autores: Rodriguez; Diego F.; Duran-Osorio; Francisca; Duarte; Yorley; Olivares; Pedro; Moglie; Yanina; Dua; Kamal; Zacconi; Flavia C. Año: 2022 Link: https://doi.org/10.3390/pharmaceutics14010033
• NOVEL N-BENZOYLIMIDAZOLIUM IONIC LIQUIDS DERIVED FROM BENZOIC AND HYDROXYBENZOIC ACIDS AS THERAPEUTIC ALTERNATIVE AGAINST BIOFILM-FORMING BACTERIA IN SKIN AND SOFT-TISSUE INFECTIONS Autores: Forero-Doria; O.; Parra-Cid; C.; Venturini; W.; Espinoza; C.; Araya-Maturana; R.; Valenzuela-Riffo; F.; Saldias; A.; Leiva; A.; Duarte; Y.; Echeverría; J.; Guzmán; L Año: 2022 Link: https://doi.org/https://doi.org/10.1016/j.bioorg.2022.105914
• SYNTHESIS MULTICOMPONENT BASED ON OTOLYLISOCYANIDE CHOLINESTERASE INHIBITORS AND COMPUTATIONAL STUDIES Autores: Camargo-Ayala; L.; Polo-Cuadrado; E.; Osorio; E.; Soto-Delgado; J.; Duarte; Y.; Prent-Peñaloza; L.; Gutiérrez; M. Año: 2022 Link: https://doi.org/https://doi.org/10.1016/j.molstruc.2022.133307
• THE TGA TRANSCRIPTION FACTORS FROM CLADE II NEGATIVELY REGULATE THE SALICYLIC ACID ACCUMULATION IN ARABIDOPSIS Autores: Fonseca; Alejandro; Urzua; Tomas; Jelenska; Joanna; Sbarbaro; Christopher; Seguel; Aldo; Duarte; Yorley; Greenberg; Jean T.; Holuigue; Loreto; Blanco-Herrera; Francisca; Herrera-Vasquez; Ariel Año: 2022 Link: https://doi.org/10.3390/ijms231911631
• TOWARD THE CHOLINESTERASE INHIBITION POTENTIAL OF TADDOL DERIVATIVES: SEMINAL BIOLOGICAL AND COMPUTATIONAL STUDIES Autores: Constantino; Andrea R.; Charbe; Nitin; Duarte; Yorley; Gutierrez; Margarita; Giordano; Ady; Prasher; Parteek; Dua; Kamal; Mandolesi; Sandra; Zacconi; Flavia C. Año: 2022 Link: https://doi.org/10.1002/ardp.202200142